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Credit: FEFU press office
Scientists from the Pacific Quantum Center of Far Eastern Federal University (FEFU) figured out how the AFV3-109 protein with slipknot structure folds and unfolds depending on temperature. The protein is typical for the viruses of the oldest single-celled organisms that can survive in the extreme conditions of underwater volcanic sources - archaea. The research outcome appears in
PLOS ONE.
Using numerical methods and applying quantum field theory that is unique for the study of proteins, the FEFU scientists have probed into the folding topology (scheme) of the AFV3-109 protein featured with a slipknot. The research unfolded in several unexpected and intriguing results.
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How are networks of neurons connected to make functional circuits? This has been a long standing question in neuroscience. To answer this fundamental question, researchers from Boston Children s Hospital and Harvard Medical School developed a new way to study these circuits and in the process learn more about the connections between them. Neural networks are extensive, but the connections between them are really small, says Wei-Chung Allen Lee, PhD, of the F.M. Kirby Neurobiology Center at Boston Children s and Harvard Medical School. So, we have had to develop techniques to see them in extremely high-resolution over really large areas and volumes. To do so, his team developed an improved process for large-scale electron microscopy (EM) a technique first developed in the 1950s using accelerated electrons beams to visualize extremely small structures.
Study: 20% of glioblastomas are fueled by overactive mitochondria
A new study has found that up to 20% of glioblastomas an aggressive brain cancer are fueled by overactive mitochondria and may be treatable with drugs currently in clinical trials.
Mitochondria are responsible for creating the energy that fuels all cells. Though they are usually less efficient at producing energy in cancer, tumor cells in this newly identified type of glioblastoma rely on the extra energy provided by overactive mitochondria to survive.
The study, by cancer scientists at Columbia University s Vagelos College of Physicians and Surgeons and Herbert Irving Comprehensive Cancer Center, was published online Jan. 11 in
Philip Morris International
Underscoring Critical Role of Science in a Smoke-Free Future, Philip Morris International Brings on Former Sanofi Exec as Chief Life Sciences Officer
Tuesday, January 12, 2021 11:04AM IST (5:34AM GMT)
Lausanne, Switzerland:
Philip Morris International Inc. (PMI) (NYSE: PM) today announced the appointment of Jorge Insuasty to the position of Chief Life Sciences Officer, effective Jan. 15, 2021. Mr. Insuasty will report to the company’s CEO, André Calantzopoulos.
“Jorge’s wealth of experience across both the pharmaceutical and consumer healthcare industries makes him the ideal candidate to succeed John O’Mullane, who is retiring,” said Calantzopoulos. “Jorge is a transformational leader in science and medicine and excels in driving product portfolio development through to market success. Science and a consumer-focused product portfolio are the cornerstones of our amb